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 25 May 2018

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News

Excessive weight gain increases GI cancer risk

This week's issue of the Journal of the American Medical Association reviews the association between obesity and cancer risk, and explores opportunities for clinical intervention in patients with excessive weight gain.

News image

The effects of overweight and obesity on diabetes, cardiovascular disease, all-cause mortality, and other health outcomes are widely known.

There is less awareness that overweight, obesity, and weight gain are associated with an increased risk of certain cancers.

Dr Greta Massetti and colleagues reviewed opportunities for clinical intervention in patients with excessive weight gain.

The research team also reviewed the association between obesity and cancer.

There was a dose-response association of weight gain and obesity with several cancers
Journal of the American Medical Association

The team reported that a recent review of more than 1000 studies concluded that sufficient evidence existed to link weight gain, overweight, and obesity with 13 cancers, including adenocarcinoma of the esophagus; cancers of the gastric cardia, colon and rectum, liver, gallbladder, pancreas, corpus uteri, ovary, kidney, and thyroid; postmenopausal female breast cancer; meningioma; and multiple myeloma.

An 18-year follow-up of almost 93 000 women in the Nurses’ Health Study revealed a dose-response association of weight gain and obesity with several cancers.

The team's most notable finding was that cancer related to overweight and obesity were increasingly diagnosed among younger people.

Dr Masetti's team concludes, "Given the time lag between exposure to cancer risk factors and cancer diagnosis, the high prevalence of overweight and obesity among adults, children, and adolescents may forecast additional increases in the incidence of cancers related to overweight and obesity."

JAMA 2017;318(20):1975-1976
29 November 2017

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