Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function.
Dr Andrew Chan and colleagues from Massachussetts, USA examined associations between PPI use and performance in tests of cognitive function.
Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim.
Dr Andrew Chan and Massachussetts, USA used prospectively collected data on medication use and other potential risk factors from 13,864 participants in the Nurses’ Health Study II who had completed a self-administered computerized neuropsychological test battery.
Multivariable linear regression models were used to examine associations between medication use and composite scores of psychomotor speed and attention, learning and working memory, and overall cognition.
The researchers observed a modest association between duration of PPI use and scores for psychomotor speed and attention.
|Duration of H2 receptor antagonists use was associated with poorer cognitive scores|
After controlling for H2 receptor antagonists use, the magnitude of this score difference was attenuated.
The team found that among individuals who did not use PPIs regularly, duration of H2 receptor antagonists use was associated with poorer cognitive scores, with the strongest association apparent for learning and working memory.
Dr Chan's team concludes, "In an analysis of data from the Nurses’ Health Study II, we did not observe a convincing association between PPI use and cognitive function."
"Our data do not support the suggestion that PPI use increases dementia risk."
"Because our primary hypothesis related to PPI use, our findings for H2 receptor antagonists should be interpreted with caution.'