Limited data describe the long-term efficacy of dietary elimination in eosinophilic esophagitis.
Dr Dellon and colleagues from North Carolina, USA assessed the long-term outcomes of food elimination diets for treatment of adults with eosinophilic esophagitis.
The research team conducted a retrospective cohort study analyzing all eosinophilic esophagitis patients receiving a food elimination diet without concomitant steroids.
Baseline data were abstracted using standardized collection forms.
Follow-up data from a mean 25-month period were collected for patients with a histological response to a food elimination diet during and after food reintroduction.
|Histological findings improved after the most restrictive diet in responders|
|Alimentary Pharmacology & Therapeutics|
The team's main outcomes were symptomatic, endoscopic and histological responses.
Of 52 patients, 18 received a 6-food food elimination diet, 32 received targeted diet, and 2 received a 6-food food elimination diet with targeted elimination.
The researchers noted that 40% of patients with an initial histological response.
Responders reported less dysphagia after treatment, and at the end of follow-up.
Significant and durable endoscopic improvements were recorded at the same time points.
The team found that histological findings improved after the most restrictive diet in responders, and remained suppressed in the 10 initial responders maintaining compliance at the end of follow-up.
Dr Dellon's team comments, "Among eosinophilic esophagitis patients responding to a food elimination diet and remaining adherent, maintenance dietary therapy produced durable long-term symptomatic, endoscopic and histological disease control."
"These long-term data confirm that a food elimination diet is an effective maintenance treatment option in select adults with eosinophilic esophagitis."