Up-to-date information regarding the recurrence rate of Helicobacter pylori after eradication therapy is not available.
Professor Lu and colleagues from China evaluated the global recurrence rate following Helicobacter pylori eradication therapy, and confirmed its association with socioeconomic and sanitary conditions.
The researchers performed a systematic search of PubMed, EMBASE and the Cochrane library to identify potentially relevant publications using the following keywords: “Helicobacter pylori” or “H. pylori” or “Hp” and “recurrence” or “recrudescence” or “reinfection” or “recurrent” or “recurred” or “re-infect*” or “relapse*.”
A total of 132 studies were analyzed, and each study was weighted according to the duration of patient-years.
|The global annual recurrence rate of Helicobacter pylori was 4%|
|Alimentary Pharmacology & Therapeutics|
The researchers found that the global annual recurrence, reinfection and recrudescence rate of Helicobacter pylori were 4%, 3%, and 2%, respectively.
The team noted that the Helicobacter pylori recurrence rate was inversely related to the human development index, and directly related to Helicobacter pylori prevalence.
Global recurrence rates remained relatively stable between 1990s, 2000s and 2010s but varied across different regions.
Professor Lu's team comments, "Helicobacter pylori recurrence remains a problem closely associated with socioeconomic and sanitary conditions."
"Methods to reduce recurrence in developing countries are needed."