Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 24 September 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Predictors of bile tree pathology in patients presenting with gallbladder disease

The latest issue of the European Journal of Gastroenterology & Hepatology identifies predictors of bile tree pathology in patients presenting with gallbladder disease.

News image

Patients with gallstone disease can present with elevated liver function tests.

It is often challenging to differentiate those with a common bile duct stone from those without a CBD stone on the basis of the liver function tests levels.

In this study,  Dr Mahmoud Rahal evaluated the predictors of a  common bile duct stones among patients presenting with symptomatic gallbladder disease and elevated liver function tests.

The team retrospectively examined all patients who had undergone a cholecystectomy between 2010 and 2015.

Patients with symptomatic cholelithiasis and increased liver function tests were included.
Total bilirubin was highly predictive of common bile duct stones with a positive predictive value of 85%
European Journal of Gastroenterology & Hepatology

Patient characteristics, imaging findings, lab findings, endoscopic interventions, and operative report were recorded and evaluated.

The diagnosis of common bile duct stones was made on the basis of ERCP and IOC findings.

The researchers included 354 patients in the final analysis.

Of these, 113 had confirmed choledocholithiasis.

The researchers noted that the prevalence of common bile duct stones among biliary colic, acute cholecystitis, and pancreatitis patients was 47%, 25%, and 26%, respectively.

The team found that γ-glutamyl transferase and direct bilirubin had the highest sensitivities for common bile duct stones among these patients.

In the setting of biliary colic, total bilirubin was highly predictive of common bile duct stones with a positive predictive value of 85%. 

In the setting of acute cholecystitis, elevated liver function tests were even less significant in predicting stones, with a positive predictive value of less than 40% for most.

Dr Rahal's team concludes, "Although γ-glutamyl transferase and bilirubin levels showed a relatively higher sensitivity for common bile ducts compared with the other liver function tests, these were not reliable enough because of high false-positive as well as false-negative values, especially in patients presenting with acute cholecystitis".

Eur J Gastroenterol Hepatol 2017: 29: 1017–1021


14 September 2017

Go to top of page Email this page Email this page to a colleague

 23 September 2017 
Lenalidomide as second-line therapy for advanced hepatocellular carcinoma: exploration of biomarkers for treatment efficacy
 23 September 2017 
Highly bioavailable silibinin nanoparticles inhibit HCV infection
 22 September 2017 
MRI for liver metastatic colorectal cancer
 22 September 2017 
Perforation after colonic endoscopic mucosal resection
 22 September 2017 
Medical management and colectomy rates
 21 September 2017 
Predicting mucosal healing in treated celiac disease patients
 21 September 2017 
Antireflux surgery and recurrence of GERD
 21 September 2017 
Adenomatous colorectal polyps in young cancer survivors
 20 September 2017 
Rifaximin and spontaneous bacterial peritonitis in cirrhosis
 20 September 2017 
Omega-3 PUFA and colorectal cancer survival
 20 September 2017 
Beta-blockers and cardiopulmonary exercise testing in liver disease
 19 September 2017 
Birth outcomes in children fathered by men treated with azathioprine
 19 September 2017 
Risk of death and statins in alcoholic cirrhosis
 19 September 2017 
Hospital-readmission risk
 18 September 2017 
Ethnic disparities and Hep C survival
 18 September 2017 
Depression and celiac disease in the USA
 18 September 2017 
Health care services in IBD
 15 September 2017 
Hemidesmosome integrity and colorectal cancer
 15 September 2017 
Herpes zoster vaccination in IBD
 15 September 2017 
Chronic pancreatitis and pancreatic cancer risk
 14 September 2017 
National survey on stopping PPIs
 14 September 2017 
Psychological impact of IBD
 14 September 2017 
Bile tree pathology in patients presenting with gallbladder disease
 13 September 2017 
Predicting clinical outcome in colorectal cancer
 13 September 2017 
Oral contraceptives increases the risk of IBD
 13 September 2017 
Mortality in cirrhosis
 12 September 2017 
Genetic factors and tobacco in IBD
 12 September 2017 
Predictors of colectomy in ulcerative colitis
 12 September 2017 
Low birthweight and pediatric NAFLD
 11 September 2017 
Proteomic analysis of IBD
 11 September 2017 
New therapies to manage Hep B
 11 September 2017 
Ethnic disparities for chronic Hep C survival
 08 September 2017 
Antibiotics and diverticulitis
 08 September 2017 
Improving adherence to colorectal cancer screening
 08 September 2017 
Preoperative workup for colorectal cancer
 07 September 2017 
Laparoscopic surgery use in Medicare patients with colon cancer
 07 September 2017 
Outreach to improve colorectal cancer screening
 07 September 2017 
Nicotine chewing gum after colorectal surgery
 06 September 2017 
Novel candidate risk genes for IBD
 06 September 2017 
PPI use and chronic kidney disease
 06 September 2017 
Colorectal cancer surgery in the very elderly patient
 05 September 2017 
Unprovoked Venous Thromboembolism and occult cancer
 05 September 2017 
Hep E seroprevalence and hemodialysis
 05 September 2017 
Antibody tests and detecting celiac disease
 04 September 2017 
Acute pancreatitis and health related quality of life
 04 September 2017 
Infliximab treatment and eHealth in IBD
 04 September 2017 
Contrast-enhanced ultrasound for diagnosis of liver cancer
 01 September 2017 
Late recurrence of Barrett’s esophagus after eradication
 01 September 2017 
Thalidomide ine children with IBD
 01 September 2017 
Occult cancer screening with unprovoked venous thromboembolism
 31 August 2017 
Asthma and IBD development
 31 August 2017 
Environmental factors and IBD
 31 August 2017 
Management of noncardiac chest pain
 30 August 2017 
Diet and increased flares in patients with ulcerative colitis in remission
 30 August 2017 
Induction of remission in pediatric Crohn's disease
 29 August 2017 
Reducing antibody formation against TNF antagonists in IBD
 29 August 2017 
Epidemiological changes of chronic hepatitis
 28 August 2017 
Hyperuricemia and NAFLD activity score
 28 August 2017 
Therapy for acute variceal hemorrhage
 28 August 2017 
Colectomy rates in ulcerative colitis

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us