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 21 October 2017

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News

Acute pancreatitis has a deleterious effect on physical health related quality of life

Acute pancreatitis has a long-term deleterious effect on physical health related quality of life, reports the most recent issue of the Clinical Gastsroenterology & Hepatology.

News image

It is not clear how acute pancreatitis affects health related quality of life.

Dr Georgios Papachristou and colleagues from Pennsylvania, USA determined the long-term independent effect of acute pancreatitis on physical and mental health related quality of life.

The researchers analyzed data from 91 patients admitted with acute pancreatitis to the University of Pittsburgh Medical Center from 2011 to 2015 who responded to telephone surveys at a median of 14 months after hospital discharge.

Individuals who did not answer the telephone survey were sent a questionnaire by regular mail.

Patients answered questions from the 12-Item Short-Form Survey, and answers were used to calculate mental component summary, and physical component summary scores with norm-based scoring.
 
Health related quality of life for these subjects was compared with that of age- and sex-matched individuals without pancreatitis identified from the North American Pancreatitis Study.

The diagnostic accuracy for intrahepatic cholangiocellular carcinoma was identical with both algorithms
Clinical Gastroenterology & Hepatology

The team controlled for other covariates using multivariable regression analysis.

At follow-up, individuals with acute pancreatitis had a significantly lower physical component summary score than did control subjects, but a similar mental component summary score.

The researchers found that a 4-point reduction of the physical component summary was attributed to acute pancreatitis after controlling for sociodemographic factors and medical comorbidities.

The team noted that only pancreatitis-related factor associated with low physical component summary score was multisystem organ failure.

Presence of abdominal pain, analgesic use, disability, and current smoking at the time of follow-up were also associated with lower physical component summary scores.

The research team noted that etiology of acute pancreatitis, disease severity, use of nutritional support, and performance of pancreatic interventions did not affect health related quality of life at follow-up.

Dr Papachristou's team concludes, "In a 14-month follow-up of patients hospitalized with acute pancreatitis, we found a meaningful, independent, and deleterious effect of acute pancreatitis in the physical health related quality of life of these patients, compared to individuals without acute pancreatitis."

"Further research is needed to determine the duration of this impairment and to evaluate the effects of modifying risk factors."

Clin Gastroenterol Hepatol 2017: 15(9): 1435–1443.e2
04 September 2017

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