Dietary factors may have a significant role in relapse of disease among patients with ulcerative colitis (UC).
However, the relationship between diet and UC is inadequately understood.
Dr Edward Barnes and colleagues analyzed data from the diet’s role in exacerbations of mesalamine maintenance study to determine whether dietary factors affect the risk of disease flares in patients with UC.
The team performed a prospective, multicenter, observational study of 412 patients, from 25 sites, with UC in remission during monotherapy with an aminosalicylate.
Patients completed a validated food frequency questionnaire at enrollment and were followed for 12 months.
|11% had a UC relapse within 1 year of study enrollment |
|Clinical Gastroenterology & Hepatology|
The researchers analyzed the relationship between diet and disease remission or flare for groups of macronutrients and micronutrients, and food groups previously associated with an increased risk of flare.
The team noted that 11% had a UC relapse within 1 year of study enrollment.
When analyzed in tertiles, increasing intake of multiple fatty acids was associated with increasing odds of relapse.
The research team noted that, only myristic acid maintained this dose–response relationship.
Other foods previously implicated in flares of UC, such as processed meat, alcohol, and foods high in sulfur, were not associated with an increased risk of flare.
Dr Barnes's team concludes, "In a prospective study of more than 400 patients with UC undergoing treatment with aminosalicylates, we associated high dietary intake of specific fatty acids, including myristic acid with an increased risk of flare."
"These findings can help design interventional studies to evaluate dietary factors in UC."