A prognostic scoring model has been devised previously to predict survival following primary tumor resection in patients with metastatic colorectal cancer and unresectable metastases.
This has yet to be validated.
Dr Min Chew and colleagues validated the proposed prognostic scoring model and create an interactive online calculator to estimate an individual’s survival after primary tumor resection.
Clinical data and survival outcomes of patients were extracted from a prospectively maintained database.
The team categorized patients into good, moderate, or poor survivor groups based on the previously proposed scoring algorithm.
|The median survival in the good prognostic group was 57 months|
|Diseases of the Colon & Rectum|
Discrimination was assessed and recalibration was performed, with the recalibrated model implemented as an interactive Web application to provide individualized survival probability.
The team conducted the study at a tertiary referral center.
The researchers included 324 consecutive patients with metastatic colorectal carcinoma and unresectable metastases who underwent primary tumor resection between 2008 and 2013.
The team's primary outcome measured was overall survival.
The researchers found that the median survival in the good, moderate, and poor prognostic groups was 57, 26, and 20 months.
The team observed significant differences in survival between the moderate and good prognostic groups, and between poor and good prognostic groups.
The model was implemented as an interactive online calculator to provide individualized survival estimation after primary tumor resection.
Dr Chew's team concludes, "The prognostic scoring model provides good prognostic stratification of survival after primary tumor resection and may be a useful tool to predict survival after primary tumor resection."