Arterial function is a marker of early atherosclerotic changes and cardiovascular disease.
Several studies have suggested the possible association between nonalcoholic fatty liver disease (NAFLD) and increased arterial stiffness.
Thus, Dr Veeravicha Jaruvongvanich and colleagues conducted a systematic review and meta-analysis to better characterize this association.
The team carried out a comprehensive search of the databases of the MEDLINE and EMBASE from inception through 2016.
All observational studies that compared arterial stiffness between NAFLD patients and healthy controls were included.
|Data was extracted from 12 studies involving 9351 NAFLD patients|
|European Journal of Gastroenterology & Hepatology|
The team measured arterial stiffness by pulse wave velocity and augmentation index.
The research team extracted data from 12 studies involving 9351 NAFLD patients, and 17,684 controls.
NAFLD is significantly associated with increased arterial stiffness as determined by carotid–femoral pulse wave velocity, brachial–ankle pulse wave velocity, and augmentation index compared with healthy controls.
Dr Jaruvongvanich's team concludes, "Our study demonstrated a higher degree of arterial stiffness in NAFLD patients compared with controls."
"However, this association might be related to the higher prevalence of cardiometabolic risk factors in NAFLD patients."
"Further studies are needed to determine an independent association between NAFLD and arterial stiffness adjusting to cardiometabolic risks."