Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma.
A sustained virological response is associated with improved outcomes, however, its impact on different ethnic groups is unknown.
Dr Nguyen and colleagues from California, USA evaluated ethnic differences in the natural history of chronic hepatitis C and the impact of sustained virological response.
The researchers conducted a cohort study of 8039 consecutive adult chronic hepatitis C patients seen at 2 medical centers in California between 1997 and 2016.
Individual chart review confirmed chronic hepatitis C diagnosis.
Asian and Hispanic but not African American patients had significantly higher cirrhosis and hepatocellular carcinoma incidence than Caucasians.
|Hispanic ethnicity was independently associated with increased cirrhosis|
|Alimentary Pharmacology & Therapeutics|
The researchers noted that Hispanic ethnicity was independently associated with increased cirrhosis, and hepatocellular carcinoma risk compared to Caucasian.
The team noted that Asian ethnicity had a significant association with cirrhosis, and hepatocellular carcinoma risk.
In patients who achieved sustained virological response, Hispanic ethnicity was no longer independently associated with cirrhosis or hepatocellular carcinoma, nor was Asian ethnicity.
The research team observed similar findings with overall survival among the ethnicities by sustained virological response status.
Dr Nguyen's team concludes, "Hispanic and Asian ethnicity was independently associated with increased cirrhosis and hepatocellular carcinoma risk."
"Achieving an sustained virological response eliminates the ethnic disparity in liver disease progression and overall survival between Hispanic and Asian vs Caucasian chronic hepatitis C patients."