Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy.
Appendectomy is associated with a lower risk of later developing UC.
Dr Pär Myrelid and colleagues from Sweden assessed the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients.
A national cohort of UC patients with a diagnosis in 1964–2010 was identified from the Swedish National Patient Register that also provided information regarding appendicitis and/or appendectomy before or after the UC diagnosis.
|Appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy|
|American Journal of Gastroenterology|
The researchers evaluated the risk for colectomy and UC-related hospital admissions.
Among 63,711 UC patients, 2,143 had appendectomy and 7,690 underwent colectomy.
The researchers found that appendectomy for appendicitis before 20 years of age, and for non-appendicitis at all ages before UC diagnosis was associated with a lower risk of colectomy, and fewer hospital admissions.
The team observed that appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy, whereas no such association was found for other pathology.
Dr Myrelid's team concludes, "Appendectomy early in life and before developing UC is associated with a lower risk of colectomy as well as UC-related hospital admissions."
"Appendectomy for appendicitis after established UC appears associated with a worse disease course, with an increased rate of subsequent colectomy."