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 13 December 2017

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News

Appendectomy and the risk of colectomy in ulcerative colitis

The most recent issue of the American Journal of Gastroenterology evaluates the association between appendectomy and the risk of colectomy in ulcerative colitis in a national cohort.

News image

Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy.

Appendectomy is associated with a lower risk of later developing UC.

Dr Pär Myrelid and colleagues from Sweden assessed the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients.

A national cohort of UC patients with a diagnosis in 1964–2010 was identified from the Swedish National Patient Register that also provided information regarding appendicitis and/or appendectomy before or after the UC diagnosis.

Appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy
American Journal of Gastroenterology

The researchers evaluated the risk for colectomy and UC-related hospital admissions.

Among 63,711 UC patients, 2,143 had appendectomy and 7,690 underwent colectomy.

The researchers found that appendectomy for appendicitis before 20 years of age, and for non-appendicitis at all ages before UC diagnosis was associated with a lower risk of colectomy, and fewer hospital admissions.

The team observed that appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy, whereas no such association was found for other pathology.

Dr Myrelid's team concludes, "Appendectomy early in life and before developing UC is associated with a lower risk of colectomy as well as UC-related hospital admissions."

"Appendectomy for appendicitis after established UC appears associated with a worse disease course, with an increased rate of subsequent colectomy."

Am J Gastroenterol 2017; 112: 1311–1319
16 August 2017

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