Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma.
A sustained virological response is associated with improved outcomes, however, its impact on different ethnic groups is unknown.
Dr Nguyen and colleagues evaluated ethnic differences in the natural history of chronic hepatitis C and the impact of sustained virological response.
The researchers conducted a cohort study of 8039 consecutive adult CHC patients seen at 2 medical centres in California between 1997 and 2016.
Individual chart review confirmed chronic hepatitis C diagnosis.
|Asian ethnicity had a significant association with cirrhosis|
|Alimentary Pharmacology & Therapeutics|
Asian and Hispanic but not African American patients had significantly higher cirrhosis and HCC incidence than Caucasians.
The researchers found that Hispanic ethnicity was independently associated with increased cirrhosis, and HCC risk compared to Caucasian.
The team observed that Asian ethnicity had a significant association with cirrhosis, and HCC risk.
In patients who achieved sustained virological response, Hispanic ethnicity was no longer independently associated with cirrhosis or HCC.
Dr Nguyen's team concludes, "Asian ethnicity was independently associated with increased cirrhosis and HCC risk."
"Similar findings were observed with overall survival among the ethnicities by sustained virological response status."