Current subgrouping of Irritable Bowel Syndrome (IBS) is exclusively based on stool consistency without considering other relevant gastrointestinal, extraintestinal somatic or psychological features.
Dr Polster and colleagues from Sweden identified subgroups based on a comprehensive set of IBS-related parameters.
Mixture model analysis was used including 13 single-item scores from the IBS-specific Gastrointestinal Symptom Rating Scale, average stool consistency and frequency from a 7-day Bristol Stool Form diary, 12 single-item extraintestinal symptom scores from the Patient Health Questionnaire-12, and anxiety and depression subscale scores from the Hospital Anxiety and Depression scale.
The resulting latent subgroups were compared regarding symptom profiles using analysis of variance followed by pair-wise comparisons.
|Subgroups showed differences in the distribution of Rome III-subtypes|
|Alimentary Pharmacology& Therapeutics|
The research team analyzed 172 IBS patients.
The optimal subgrouping showed 6 latent groups, including constipation with low comorbidities, constipation with high comorbidities, diarrhea with low comorbidities, diarrhea and pain with high comorbidities, mixed GI symptoms with high comorbidities, and a mix of symptoms with overall mild severity.
The research team found that subgroups showed differences in the distribution of Rome III-subtypes, IBS severity, presence of anxiety and depression, and gender, but not regarding age, IBS duration or reported post-infectious onset of IBS.
Dr Polster's team comments, "This model-based subgrouping of IBS partly supports the distinction of subgroups based on bowel habits, but additionally distinguishes subgroups with or without co-morbid extraintestinal somatic and psychological symptoms."
"The resulting groups show specific profiles of symptom combinations."