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 17 October 2017

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News

Understanding contraindications of biologic therapies for use in IBD

Understanding the cautions and contraindications of immunomodulator and biologic therapies for use in inflammatory bowel disease, reports the most recent issue of the Inflammatory Bowel Diseases.

News image

Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases for which there are no cures.

These diseases are immunopathogenic, and medical treatment is centered on the temperance of a dysregulated immune response to allow mucosal healing and prevent the sequelae of fistulation and stenosis.

Accordingly, the armamentarium of medications, which has expanded immensely in recent history, is not without significant infectious and neoplastic risks.

Patient registries provide knowledge to calculate the incidence of safety outcomes
Inflammatory Bowel Diseases

Many of these untoward effects can be mitigated by screening and avoidance of contraindicated medications.

Dr Matthew Cohn and colleagues reviewed the cautions for use of immunomodulators, anticytokine, and α4-integrin antagonists.

The researchers noted that potential adverse events are further complicated by substantial heterogeneity in disease phenotype in the inflammatory bowel disease population.

The team large patient registries and databases provide considerable experience, and knowledge to calculate the incidence of safety outcomes.

Dr Cohn's team comments, "To identify rarer outcomes after prolonged therapy, more prospective studies and continued adverse event reporting will aid safe application and minimize potential harms."

Inflamm Bowel Dis 2017: 23(8): 1301–1315
07 August 2017

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Breastfeeding and the risk of IBD
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Colorectal cancer screening and postpolypectomy surveillance colonoscopy
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Continuity of care after colorectal surgery
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Treating patients with HCV and severe renal impairment
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Global recurrence of H. pylori
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Fecal microbiota transplantation for ulcerative colitis
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Quality standards in upper gastrointestinal endoscopy
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Follow-up of positive results on fecal blood tests
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Global recurrence rate of H. pylori
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Clostridium difficile infection after ileostomy reversal
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Cow's milk–based formula and development of celiac disease
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Propofol for outpatient colonoscopy
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Pediatric candidates on the transplant wait list
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Incidence of sepsis in the USA
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Quality of life after chemoradiation in rectal cancer
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Peptic ulcer disease diagnosed in acute upper endoscopy
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Clinical practice guidelines in colon cancer
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Antibody tests and detecting celiac disease
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Novel candidate risk genes for IBD
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Environmental factors and IBD
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Full publication of Gastroenerology abstracts
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Interferon-free therapy in advanced liver disease
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Burden of NAFLD with advanced fibrosis in the USA
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Laparoscopic surgery use in Medicare patients with colon cancer
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Inpatient Gastroenterology training experience
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Proteomic analysis of IBD
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Social networking-based discussion group by ERCP doctors
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Incidence of biopsy-verified celiac disease
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Predictors of nonadherence in IBD
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Hep C treatment in the era of direct-acting anti-viral agents
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Factors associated with the risk of metachronous gastric neoplasm
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Treatment of hyperactive delirium in advanced cancer
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Lenalidomide for advanced liver cancer
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Silibinin nanoparticles inhibit HCV infection
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Perforation after colonic endoscopic mucosal resection
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Medical management and colectomy rates
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Antireflux surgery and recurrence of GERD
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Omega-3 PUFA and colorectal cancer survival
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Birth outcomes in children fathered by men treated with azathioprine
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Hospital-readmission risk

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