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 21 November 2017

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News

Stool antigen test accurately detects H. pylori after eradication therapy

The stool antigen test can accurately identify patients in whom eradication of Helicobacter pylori was successful, 7 days after completion of therapy, claim researchers from Europe and the USA.

News image

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The team investigated the use of the stool antigen test for the detection of Helicobacter pylori after eradication therapy.

The findings of the study were published in the latest issue of the Annals of Internal Medicine.

In the prospective, blinded study, 84 H. pylori-infected patients, undergoing endoscopy for upper abdominal symptoms, completed triple eradication therapy.

The patients were assessed at baseline and on day 35 after the completion of eradication therapy.

All underwent endoscopy with histologic examination, rapid urease test and culture, urea breath test, and a stool antigen test.

Stool antigen test:
Sensitivity: 94%
Specificity: 97%
Annals of Internal Medicine
The stool antigen test was also performed on Days 3, 7, 15, 21, 28, and 35 after completion of therapy.

Compared with the endoscopic tests on Day 35 after antimicrobial therapy, the urea breath test had a sensitivity of 94% and a specificity of 100%.

The researchers found that the stool antigen test had a sensitivity of 94% and a specificity of 97%.

On Day 7 after treatment, the stool antigen test was predictive of eradication (positive predictive value, 100%; negative predictive value, 91%).

Dr Dino Vaira, of the University of Bologna, Italy, concluded on behalf of his group, "A positive result on the stool antigen test, 7 days after completion of therapy, identifies patients in whom eradication of H. pylori was unsuccessful."

Ann Intern Med 2002; 136: 280-7
19 February 2002

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