Clostridium difficile infection (CDI), the most common health care–associated infection, often recurs.
Fecal microbiota transplantation is increasingly used to treat multiply recurrent CDI.
Dr James Lewis and colleagues determined whether the incidence of multiply recurrent CDI is increasing in proportion to CDI and to identify risk factors for multiply recurrent CDI.
The research team performed a retrospective cohort study of 38,911,718 commercially insured patients in the OptumInsight Clinformatics Database, of whom 45,341 developed CDI.
The team measured age- and sex-standardized incidence rates for CDI and multiply recurrent CD.
|From 2001 to 2012, the annual incidence of multiply recurrent CDI per 1000 person-years increased by 189%|
|Annals of Internal Medicine|
From 2001 to 2012, the annual incidence of CDI and multiply recurrent CDI per 1000 person-years increased by 43%, and 189%, respectively.
The increase in multiply recurrent CDI incidence was independent of known risk factors for CDI.
The team found that those who developed multiply recurrent CDI were older, and were more likely to be female, and to have used antibiotics, proton-pump inhibitors, or corticosteroids within 90 days of CDI diagnosis.
The researchers noted that chronic kidney disease, and diagnosis in a nursing home were also associated with increased risk for multiply recurrent CDI.
Dr Lewis' team concludes, "Relative to CDI, multiply recurrent CDI incidence has disproportionately increased, indicating a rising demand for multiply recurrent CDI therapies."