Early appendectomy is inversely associated with the development of UC.
However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course.
Dr Alyssa Parian and colleagues described the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis.
Using the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy.
In addition, the researchers performed a meta-analysis of studies that examined the association between appendectomy and colectomy.
|63 appendectomies were performed prior to UC diagnosis|
The team included 2980 patients with UC.
The researchers noted that 111 of patients with UC had an appendectomy, of which 63 were performed prior to UC diagnosis and 48 after diagnosis.
The team noted that appendectomy performed at any time was an independent risk factor for colectomy, with appendectomy performed after UC diagnosis most strongly associated with colectomy.
An updated meta-analysis showed appendectomy performed either prior to or after UC diagnosis had no effect on colectomy rates.
Dr Parian's team concludes, "Appendectomy performed at any time in relation to UC diagnosis was not associated with a decrease in severity of disease."
"In fact, appendectomy after UC diagnosis may be associated with a higher risk of colectomy."
"These findings question the proposed use of appendectomy as treatment for UC."