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 21 October 2017

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News

Health-related quality of life in children and adults with eosinophilic esophagitis

Published ahead of print, the Alimentary Pharmacology & Therapeutics examines health-related quality of life in children and adults with eosinophilic esophagitis—instruments for measurement and determinant factors.

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Several measures have been used to assess the health-related quality of life of patients with eosinophilic esophagitis.

Dr Lucendo and colleagues systematically reviewed these health-related quality of life measures, to appraise measurement properties of specific instruments, and evaluated determinant factors influencing health-related quality of life in pediatric and adult eosinophilic esophagitis patients.

The team searched the PubMed, Embase, Scopus, Web of Science (WOS) and PsycINFO databases for documents providing original information on the development of measurement tools and/or evaluation of health-related quality of life outcomes in eosinophilic esophagitis patients of all ages.

Of the 596 references identified, data was collected from 34 studies including a total of 1,689 individual patients.

Severity of endoscopic features and female gender may also determine an impaired health-related quality of life
Alimentary Pharmacology & Therapeutics

The researchers noted that 3 disease-specific health-related quality of life measures in eosinophilic esophagitis covering different aspects of patients’ lives and developed in English, were scored positive regarding measurement properties.

The PedsQL inventory, and the Peds-quality of life eosinophilic esophagitis module were the generic and specific instruments respectively used in children, while the SF-36 and eosinophilic esophagitis-quality of life-A were the most used questionnaires in adults.

Patients with eosinophilic esophagitis show an impaired health-related quality of life compared to controls, which greatly depends on symptom severity and disease duration.

Severity of endoscopic features and female gender may also determine an impaired health-related quality of life.

The research team noted the effect of treatments on health-related quality of life requires further assessment.

Dr Lucendo's team concludes, "Health-related quality of life is a relevant outcome that should be considered in clinical practice and research of eosinophilic esophagitis."

"Further validation studies in several languages and populations are required to support the use of disease-specific health-related quality of life measures."

Aliment Pharmacol Ther 2017: Early view DOI: 10.1111/apt.14194 
27 June 2017

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