Chronic pancreatitis is a progressive inflammatory disease of the pancreas.
The currently available treatment of chronic pancreatitis is aimed at controlling symptoms and managing complications.
Unfortunately, no specific treatment is available to halt the progression of the disease process because the pathophysiological perturbations in chronic pancreatitis are not well understood.
|Therapies acting on pancreatic stellate cells appear promising|
|Digestive Diseases & Sciences|
In this review, Soumya Jagannath and colleagues discuss various therapeutic targets and investigational agents acting on these targets.
Dr Jagannath's team concludes, "Among these, therapies modulating immune cells and those acting on pancreatic stellate cells appear promising and may translate into clinical benefit in near future."
"However, these experimental therapies are mostly in animal models and they do not recapitulate all aspects of human disease."
"Still they may be beneficial in developing effective therapeutic modalities to curb inflammation in chronic pancreatitis."