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 14 December 2017

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News

Predictor of long-term clinical remission in patients with Crohn's disease

A study in the latest European Journal of Gastroenteroloy investigates small-bowel mucosal healing assessment by capsule endoscopy as a predictor of long-term clinical remission in patients with Crohn's disease.

News image

Capsule endoscopy may be used for the evaluation and follow-up of patients with Crohn’s disease.

Capsule endoscopy scores correspond to the degree of mucosal inflammation, a major therapeutic target.

Dr Yaron Niv performed a meta-analysis and systematic review to determine whether mucosal healing assessment by capsule endoscopy may serve as a predictor of clinical remission in patients with Crohn’s disease.

The team identified observational or controlled English-language full-text studies assessing mucosal healing by capsule endoscopy in patients with Crohn’s disease up to 2016.

The mucosal healing capsule endoscopy score was associated with improved outcome
European Journal of Gastroenterology & Hepatology

The research team searched PubMed, Embase, Central, Medline, and Scopus using the key words ‘mucosal healing’ and ‘capsule endoscopy’.

The team identified 5 observational studies including 142 patients from 5 countries that fulfilled the inclusion criteria.

No publication bias was found by funnel plot.

The researchers noted that the mucosal healing capsule endoscopy score was significantly associated with improved outcome after a follow-up of 12 weeks to 24 months, with an odds ratio of 11.

The degree of heterogeneity among the studies was small.

Dr Niv's team commented, "Endoscopy scores may play a role in the long-term prognostic evaluation of patients with Crohn’s disease."

"Our results may be accepted as proof of concept, but larger studies are needed to corroborate these findings."

Eur J Gastroenterol Hepatol 2017: 29(7): 844–848
12 June 2017

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