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 13 December 2017

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News

Laboratory model for excluding non-alcoholic fatty liver disease

Published ahead of print, the Alimentary Pharmacology & Therapeutics investigates laboratory parameter-based machine learning model for excluding non-alcoholic fatty liver disease in the general population.

News image

Non-alcoholic fatty liver disease (NAFLD) affects 20%-40% of the general population in developed countries and is an increasingly important cause of hepatocellular carcinoma.

Electronic medical records facilitate large-scale epidemiological studies, existing NAFLD scores often require clinical and anthropometric parameters that may not be captured in those databases.

Dr Wong and colleagues from Hong Kong developed and validated a laboratory parameter-based machine learning model to detect NAFLD for the general population.

The team randomly divided 922 subjects from a population screening study into training and validation groups.

The NAFLD ridge score achieved an area under the receiver operating curve of 0.87 in the training groups
Alimentary Pharmacology & Therapeutics

The researchers diagnosed NAFLD by proton-magnetic resonance spectroscopy.

On the basis of machine learning from 23 routine clinical and laboratory parameters after elastic net regulation, the researchers evaluated the logistic regression, ridge regression, AdaBoost and decision tree models.

The areas under receiver-operating characteristic curve of models in validation group were compared.

The research team selected 6 predictors including alanine aminotransferase, high-density lipoprotein cholesterol, triglyceride, hemoglobin A1c, white blood cell count and the presence of hypertension.

The NAFLD ridge score achieved an area under the receiver operating curve of 0.87 and 0.88 in the training and validation groups, respectively.

The researchers found that using dual cut-offs of 0.24 and 0.44, NAFLD ridge score achieved 92% sensitivity, and 90% specificity with corresponding negative and positive predictive values of 96% and 69%, and 87% of overall accuracy among 70% of classifiable subjects in the validation group.

The team observed that 30% of subjects remained indeterminate.

Dr Wong's team concludes, "NAFLD ridge score is a simple and robust reference comparable to existing NAFLD scores to exclude NAFLD patients in epidemiological studies."

Aliment Pharmacol Ther 2017: Early view DOI: 10.1111/apt.14172 
07 June 2017

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