Gastric infection with Helicobacter pylori can lead to chronic inactive gastritis, atrophy and intestinal metaplasia.
Dr Sonnenberg and colleagues from Oregon, USA performed a cross-sectional study to investigate these changes among different socioeconomic and ethnic groups within the USA.
The researchers used the Miraca Life Sciences database, an electronic depository of clinicopathological records from patients distributed throughout the USA, to extract data from 487,587 patients who underwent esophago-gastro-duodenoscopy with biopsy between 2008 and 2014.
The researchers then classified patients into ethnic and socioeconomic categories using previously validated algorithms, as well as ZIP code-based information derived from the 2011-2012 US Census.
|The prevalence decreased with rising levels of income or college education|
|Alimentary Pharmacology & Therapeutics|
The team found that the prevalence of Helicobacter pylori increased significantly until the age-group 40-49, before it leveled off and started a gradual decrease.
The research team observed that the prevalence of chronic inactive gastritis, atrophy, and intestinal metaplasia increased significantly with age.
The prevalence of Helicobacter pylori, chronic inactive gastritis, intestinal metaplasia, and atrophy decreased significantly with the percentage of Whites per ZIP code.
The prevalence of all 4 diagnoses also decreased significantly with rising levels of income or college education.
Helicobacter pylori, chronic inactive gastritis, atrophy and intestinal metaplasia were more common among Hispanics and the influence of income or college education less pronounced than in the entire population.
The team found that Helicobacter pylori, chronic inactive gastritis, atrophy, and intestinal metaplasia were also more common among East-Asians, Helicobacter pylori, and atrophy decreasing with rising income but remaining unaffected by levels of college education.
Dr Sonnenber's team concludes, "Ethnicity and socioeconomic factors influence the occurrence of Helicobacter pylori gastritis, and its progression to chronic inactive gastritis, atrophy or intestinal metaplasia."