The incidence of paediatric inflammatory bowel disease (IBD) diagnosed before age 10 years is reportedly increasing, but national data are limited.
Dr Hussey and colleagues from Ireland characterized the epidemiology, phenotype and clinical outcomes of children diagnosed with inflammatory bowel disease before age 10 years, and compare with data from children diagnosed aged 10-16 years.
A review of all Irish cases of early onset inflammatory bowel disease presenting between 2000 and 2014 was undertaken and compared to a cohort of later onset pediatric inflammatory bowel disease patients.
Diagnostic investigations, phenotype, treatments, and long-term clinical and surgical outcomes were analysed.
|The incidence of early onset IBD increased by 0.6 per 100 000 per year|
|Alimentary Pharmacology & Therapeutics|
The researchers identified 190 children with early onset inflammatory bowel disease.
The research team noted that the incidence of early onset inflammatory bowel disease increased by 0.6 per 100 000 per year, with a significant increase in ulcerative colitis by 0.06 per 100 000 per year.
The team found that males with Crohn's disease had more upper gastrointestinal disease, more extensive disease distribution, and more severe disease activity at presentation than females.
Fewer patients with early onset than later onset Crohn's disease had ileocolonic disease.
The researchers observed more relapses in the first year post-diagnosis in early onset than later onset IBD.
Dr Hussey's team concludes, "Early onset inflammatory bowel disease is increasing in incidence."
"Males have more extensive and severe disease phenotypes, and younger patients have higher relapse rates than older children."
"Further research to explain these findings is warranted."