The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is closely associated with the co-occurrence of multiple pathological conditions characterizing the metabolic syndrome, obesity in particular.
However, NAFLD also develops in lean subjects, whose risk factors remain poorly defined.
Drs Sookoian and Pirola from Argentina performed a meta-analysis of 15 studies, along with the data pertaining to their own population.
Data from lean and obese patients with NAFLD were analyzed, and lean and obese subjects without NAFLD served as controls.
|NAFLD is a modifier of the level of blood lipids|
|Alimentary Pharmacology & Therapeutics|
Relative to the lean non-NAFLD controls, the team observed that lean patients with NAFLD were older, and exhibited the entire spectrum of the metabolic syndrome risk factors.
The team found they had a significant increase in plasma glucose levels, and HOMA-IR, blood lipids, systolic and diastolic blood pressure, and waist circumference.
The researchers noted that the overall alterations in the obese group were much more severe when compared to lean subjects, regardless of the presence of NAFLD.
The team suggested that NAFLD is a modifier of the level of blood lipids.
Dr Sookoian and colleague conclude, "Lean and obese patients with NAFLD share a common altered metabolic and cardiovascular profile."
"The former, while having normal body weight, showed excess of abdominal adipose tissue as well as other metabolic syndrome features."