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 28 April 2017

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News

Risk factors for infection after living donor liver transplantation

A study in the latest issue of Liver Transplantation examines the epidemiology and risk factors for infection after living donor liver transplantation.

News image

The epidemiology of infections after living donor liver transplantation is limited. 

Dr Cybele Lara Abad and colleagues from Philippines studied the epidemiology and risk factors of infections after living donor liver transplantation. 

The medical records of 223 adult patients who underwent living donor liver transplantation from 2000 to 2015 were reviewed for all infections occurring up to 1 year. 

The researchers estimated the cumulative incidence of infection using the Kaplan-Meier product limit method. 

Risk factors were analyzed with time-dependent Cox regression modeling. 

The team reported that the majority of patients were Caucasian and male, and the median age at transplantation was 55 years. 

The most common indication for transplantation was primary sclerosing cholangitis. 

The researchers found that a total of 122 patients developed an infection during the follow-up period, with the majority of these occurring within 30 days after transplantation. 

Enterococcus sp. was the most frequent pathogen identified. 

The team showed that increased Model for End-Stage Liver Disease (MELD) score, history of recurrent infections prior to transplant, Roux-en-Y anastomosis, increased log-number of packed red blood cell transfusions, and biliary complications were independently associated with a higher risk of infection. 

Infections occur commonly after living donor liver transplantation, with most infections occurring early and being related to the hepatobiliary system. 

Dr Abad's team concludes, "Higher MELD scores, the type of biliary anastomosis, presence of biliary complications, and prior pretransplant infections are independently associated with a higher risk for infections."

Liver Transplant 2017: 23(4): 465477
21 April 2017

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