Transplacental transfer of infliximab and adalimumab results in detectable drug levels in the cord blood and infant.
Dr Seow and colleagues from Canada determined if pregnancy influenced the pharmacokinetics of anti-TNF agents in women with inflammatory bowel disease.
The team prospectively recruited 25 women from the University of Calgary inflammatory bowel disease (IBD) pregnancy clinic on maintenance infliximab or adalimumab with serum bio-banking performed each trimester.
Infliximab trough and adalimumab steady-state levels were the outcomes of interest and were analysed using the ANSER infliximab and adalimumab assays.
|Infliximab trough levels increased during pregnancy, by about 4 μg/mL per trimester|
|Alimentary Pharmacology & Therapeutics|
Multivariate linear mixed-effects models were constructed to assess infliximab and adalimumab drug levels during pregnancy adjusting for the clinical covariates of albumin, BMI and CRP.
The team reported that 15 women received infliximab and 10 women with 11 pregnancies were treated with adalimumab.
Median age was about 30 years, and median disease duration was about 9 years.
The research team found that the median trough infliximab concentrations were almost 9 μg/mL, 10 μg/mL, and 21 μg/mL at trimesters 1, 2 and 3 respectively.
The team documented significant changes in albumin and BMI but not CRP throughout pregnancy.
After adjusting for albumin, BMI and CRP, infliximab trough levels increased during pregnancy, by about 4 μg/mL per trimester, while adalimumab drug levels remained stable.
Dr Seow's team concludes, "Infliximab levels rise during pregnancy, whereas adalimumab levels remain stable after accounting for changes in albumin, BMI and CRP."
"Therapeutic drug monitoring in the second trimester may be useful in guiding dosing in the third trimester."