The incidence and mortality of hepatocellular carcinoma have been reported to be plateauing in the United States.
The United States has large racial, ethnic, and regional variation.
Dr Hashem El-Serag and colleagues from Texas, USA collected data from all 50 states to better analyze changes in hepatocellular carcinoma incidence in the entire United States.
The researchers collected data from the US Cancer Statistics registry, which covers 97% of the population, and calculated adjusted incidence rates.
The team assessed annual trends among sociodemographic, and geographic subgroups using joinpoint analysis.
|Hepatocellular carcinoma incidence increased to 7 per 100,000 in 2012|
Hepatocellular carcinoma incidence increased from 4 per 100,000 in 2000 to 7 per 100,000 in 2012, increasing by 5% annually between 2000 and 2009, but only by 0.7% annually from 2010 through 2012.
The team found that the average annual percentage change (AAPC) between 2000 and 2012 was higher in men than in women, and highest in 55- to 59-year-old individuals, and 60- to 64-year-old individuals.
By 2012, rates in Hispanics surpassed those in Asians, and rates in Texas surpassed those in Hawaii.
The researchers observed geographic variation within individual race and ethnic groups was observed, but rates were highest in all major race and ethnic groups in Texas.
Dr El-Serag's team concludes, "In an analysis of the incidence of hepatocellular carcinoma in all 50 US states, we found the rate of increase in hepatocellular carcinoma to have slowed from 2010 through 2012."
"However, incidence is increasing in subgroups such as men ages 55 to 64 years old—especially those born in the peak era of hepatitis C virus infection and among whites/Caucasians. Rates in Hispanics have surpassed those in Asian Americans."
"We observed geographic differences, with Texas having the highest age-adjusted hepatocellular carcinoma rates nationwide.