Patients with Barrett's oesophagus may be at increased risk of mortality overall, and cardiovascular disease has been suggested as the main underlying cause of death.
Dr Erichsen and colleagues from Denmark examined cause-specific mortality, and risk of cardiovascular events among patients with Barrett's esophagus.
Utilizing existing Danish data sources, the researchers identified all patients with histologically verified Barrett's esophagus, and 123,526 members of the general population matched by age, sex and individual comorbidities.
The research team calculated cause-specific mortality rates and incidence rates of cardiovascular diseases.
|Patients with Barrett's had a 71% increased risk of overall mortality|
|Alimentary Pharmacology & Therapeutics|
The team then compared rates between patients with Barrett's esophagus, and the general population comparison cohort, using stratified Cox proportional hazard regression.
The research team found that patients with Barrett's esophagus had a 71% increased risk of overall mortality.
The cause-specific mortality rate per 1000 person-years for patients with Barrett's esophagus was 9 for cardiovascular diseases, 15 for non-esophageal cancers, and 5 for oesophageal cancer.
Compared to the general population cohort, corresponding hazard ratios were 1.3, 1.8, and 19.4, respectively.
The incidence rates of cardiovascular diseases per 1000 person-years for Barrett's esophagus patients and for persons from the general population cohort, respectively, varied from 0.4 and 0.2 for subarachnoid bleeding to 8 and 6 for congestive heart failure.
Dr Erichsen's team concludes, "Prophylactic measures targeted at cardiovascular diseases and non-esophageal cancers potentially could be more important than measures against esophageal cancer, for improving prognosis among patients with Barrett's esophagus."