Reported global incidence and prevalence values for achalasia vary widely, from 0.03 to 1.63 per 100,000 persons per year and from 1.8 to 12.6 per 100,000 persons per year, respectively.
Dr Peter Kahrilas and colleagues from Illinois, USA reconciled these low values with findings from a major referral center, in central Chicago, and has determined the incidence and prevalence of achalasia to be much greater.
The research team collected data from the Northwestern Medicine Enterprise Data Warehouse database of adults residing in Chicago with an encounter diagnosis of achalasia from 2004 through 2014.
Patient files were reviewed to confirm diagnosis and residential address.
US Census Bureau population data were used as the population denominator.
The team encountered every incident case in the city to calculate incidence and prevalence estimates.
Data were analyzed for the city at large and for the 13 zip codes surrounding the Northwestern Memorial Hospital (NMH), the NMH neighborhood.
|Estimated yearly incidences ranged from 0.8 to 1.4 per 100,000 citywide|
|Clinical Gastroenterology & Hepatology|
The researchers identified 379 cases that met the full inclusion criteria, and of these, 246 were incident cases.
Among these, 132 patients resided in the NMH neighborhood, 89 of which were incident cases.
The research team found that estimated yearly incidences were stable over the study period, ranging from 0.8 to 1.4 per 100,000 citywide, and from 1.4 to 4.6 per 100,000 in the NMH neighborhood.
The team observed that the corresponding prevalence values increased progressively, from 5 to 14 per 100,000 citywide, and from 16 to 33 per 100,000 in the NMH neighborhood.
Dr Kahrilas' concludes, "The incidence and prevalence of achalasia in central Chicago diagnosed using state-of-the-art technology and diagnostic criteria are at least 2- to 3-fold greater than previous estimates."
"Additional studies are needed to determine the generalizability of these data to other regions."