Epidemiology studies have been carried out to investigate the association between alcohol consumption and the risk of gallstone disease, but the results remain controversial.
Dr Jiantao Wang and colleagues carried out a meta-analysis to quantitatively summarize the evidences from observational studies on alcohol consumption and the risk of gallstone disease.
Eligible studies published in English were identified by searching PubMed, Web of Science, and Embase databases.
The research team identified 8 cohort studies, and 10 case–control studies to include in a meta-analysis.
|The risk of gallstone disease decreased by 12% for each 10g/day increment in alcohol consumption|
|European Journal of Gastroenterology & Hepatology|
The team found that the pooled relative risk of gallstone disease for the highest versus the lowest alcohol consumption was 0.62.
Statistically significant associations were also found in stratified analysis by study design.
With respect to sex, the researchers observed that both men, and women showed statistically significant associations between alcohol consumption and the risk of gallstone disease.
A linear dose–response relationship was found between alcohol consumption and gallstone disease risk, and the risk of gallstone disease decreased by 12% for each 10 g/day increment in alcohol consumption.
Dr Wang's team concludes, "This meta-analysis suggests that alcohol consumption is associated with significantly decreased risk of gallstone disease."