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 24 May 2018

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News

American Gastroenterological Association guidelines for acute liver failure

The most recent issue of the American Journal of Gastroenterology reports on the American Gastroenterological Association Institute guidelines for the diagnosis and management of acute liver failure.

News image

Briefly, the American Gastroenterological Association Institute (AGA) process for developing clinical practice guidelines incorporates Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, and best practices as outlined by the Institute of Medicine.

Dr Steven Flamm and colleagues from Illinois, USA used GRADE methodology to prepare the background information for the guideline and the technical review that accompanies it. 

Quality of evidence was a key factor in determining the strength of each recommendation
American Journal of Gastroenterology
The team report that optimal understanding of this guideline will be enhanced by reading applicable portions of the technical review. 

The guideline panel and the authors of the technical review met face-to-face on 2016, to discuss the quality of evidence, and consider other factors relevant for the risk-benefit assessment of the recommendations. 

The guideline authors subsequently formulated the recommendations. 

Dr Flamm's team comments, "Although quality of evidence was a key factor in determining the strength of each recommendation, we also considered the balance between the benefit and harm of interventions, patients’ values and preferences, and resource utilization."

Am J Gastroenterol 2017: 152(3): 644–647 
28 February 2017

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