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 17 December 2017

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News

High-dose Vitamin D3 in patients with Crohn’s disease in remission

The latest issue of the Digestive Diseases & Sciences evaluates the impact of high-dose Vitamin D3 supplementation in patients with Crohn’s disease in remission.

News image

Dr Neeraj Narula and colleagues assessed the tolerability, and efficacy of high-dose vitamin D3 in patients with Crohn’s disease (CD).

The research team performed a randomized, double-blind placebo-controlled trial of high-dose vitamin D3 at 10,000 IU daily compared to 1000 IU daily for 12 months in patients with CD in remission.

The team's primary outcome was change in serum 25-hydroxy-vitamin D levels.

The researchers' secondary outcomes included clinical relapse rates and changes in mood scores.

High-dose vitamin D3 at 10,000 IU daily improved 25-hydroxy-vitamin D levels
Digestive Diseases & Sciences

High-dose vitamin D3 at 10,000 IU daily significantly improved 25-hydroxy-vitamin D levels from a mean of 73.5 nmol/L.

The team found that the rate of relapse was not significantly different between patients receiving low- and high-dose vitamin D3.

In per-protocol analysis, the researchers observed that the clinical relapse of Crohn’s disease was less frequently observed in patients receiving a high dose compared to those receiving a low dose of 1000 IU daily.

The research team noted that improvement in anxiety and depression scores, and a good safety profile were observed in both groups treated with vitamin D3.

Dr Narula's team concludes, "Oral supplementation with high-dose vitamin D3 at 10,000 IU daily significantly improved serum 25-hydroxy-vitamin D levels."

"Rates of clinical relapse were similar between both groups."

"Larger studies using high-dose vitamin D3 for treatment of inflammatory bowel diseases are warranted."

Dig Dis Sci 2017: 62(2): 448–455
24 February 2017

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