Studies on the outcome of ileocecal resection in pediatric Crohn's disease (CD) have a limited follow-up and fail to assign predictors of adverse outcomes.
Dr Patrick van Rheenen and colleagues investigated the complication and disease recurrence rates, and identified risk factors for these adverse outcomes after ileocecal resection for pediatric CD.
The research team performed a retrospective cohort analysis of all children that underwent ileocecal resection as first intestinal resection for CD derived from 7 tertiary hospitals in the Netherlands.
Risk factors were identified using multivariable analysis.
|Severe postoperative complications rate was 10%|
|Inflammatory Bowel Diseases|
The researchers evaluated 122 children.
The team observed that severe postoperative complications rate was 10%.
Colonic disease, microscopically positive resection margins, and emergency surgery were risk factors for severe complications. Clinical and surgical recurrence rates after 1, 5 and 10 years were 19%, 49%, 71% and 2%, 12%, 22%, respectively.
Female sex was a risk factor for clinical recurrence, whereas ileocecal disease, and microscopically positive resection margins were risk factors for surgical recurrence.
The research team found that immediate postoperative therapy reduced the risk of both clinical, and surgical recurrence.
Dr van Rheenan's team concludes, "Ileocecal resection is an effective and durable treatment of pediatric CD, although postoperative complications occur frequently."
"Postoperative therapy may be started immediately to prevent disease recurrence."