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 24 October 2017

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News

Risk of surgery and mortality in elderly-onset IBD

This month's issue of the Inflammatory Bowel Diseases characterized IBD-related outcomes in this population.

News image

As the prevalence of inflammatory bowel disease (IBD) increases in the elderly population, Dr Geoffrey Nguyen and colleagues characterized IBD-related outcomes in this population.

The researchers identified incident IBD cases in Ontario, Canada between 1999 and 2008 and categorized subjects by age at diagnosis as young adults, middle-age adults, and elderly from within population-based health administrative data. 

The research team determined the risk of IBD-related surgery and mortality in those with elderly-onset IBD compared with other age groups.

Of 21,218 persons with IBD, there were 1749 cases of elderly-onset ulcerative colitis (UC), and 725 cases elderly-onset Crohn's disease (CD). 

The leading cause of death in elderly UC was solid malignancies accounting for 23% of deaths
Inflammatory Bowel Diseases
Elderly UC had higher rates of IBD-related surgery than those with young-adult UC, although there was no difference in surgical rates between age groups in CD. 

The researchers found that IBD-specific mortality was higher in elderly-onset CD compared with that in middle-age CD, and young adult CD but was not different by age in UC. 

The research team noted that the leading cause of death in elderly UC and CD was solid malignancies accounting for 23% and 26% of deaths, respectively, whereas IBD was third most frequent cause of death accounting for 6% and 9% of deaths, respectively.

Dr Nguyen's team commented, "Elderly-onset patients with UC were more likely to undergo surgery while elderly-onset patients with CD exhibited higher IBD-specific mortality than those with younger-onset disease."

"These findings should prompt more optimized disease management in elderly IBD."

Inflamm Bowel Dis 2017: 23(2):218-223
03 February 2017

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