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 19 October 2017

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News

Risk of surgery and mortality in elderly-onset IBD

This month's issue of the Inflammatory Bowel Diseases determined the risk of IBD-related surgery, and mortality in those with elderly-onset IBD compared with other age groups.

News image

As the prevalence of inflammatory bowel disease (IBD) increases in the elderly population, Dr Geoffrey Nguyen and colleagues characterized IBD-related outcomes in this population.

The researchers identified incident IBD cases in Ontario, Canada between 1999 and 2008 and categorized subjects by age at diagnosis as young adults, middle-age adults, and elderly from within population-based health administrative data. 

The research team determined the risk of IBD-related surgery, and mortality in those with elderly-onset IBD compared with other age groups.

Of 21,218 persons with IBD, there were 1749 cases of elderly-onset ulcerative colitis (UC), and 725 cases elderly-onset Crohn's disease (CD). 

The leading cause of death in elderly UC was solid malignancies accounting for 23% of deaths
Inflammatory Bowel Diseases
The team found that elderly UC had higher rates of IBD-related surgery than those with young-adult UC, although there was no difference in surgical rates between age groups in CD. 

The researchers observed that IBD-specific mortality was higher in elderly-onset CD compared with that in middle-age CD, and young adult CD but was not different by age in UC. 

The leading cause of death in elderly UC and CD was solid malignancies accounting for 23% and 26% of deaths, respectively, whereas IBD was third most frequent cause of death accounting for 6% and 9% of deaths, respectively.

Dr Nguyen's team commented, "Elderly-onset patients with UC were more likely to undergo surgery while elderly-onset patients with CD exhibited higher IBD-specific mortality than those with younger-onset disease."

"These findings should prompt more optimized disease management in elderly IBD."

Inflamm Bowel Dis 2017: 23(2):218-223 
30 January 2017

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