Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn’s disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel disease (IBD) patients is scarce.
Dr Gert Huppertz-Hauss and colleagues from Norway assessed fatigue scores, and the prevalence of chronic fatigue in IBD patients 20 years after diagnosis and to identify variables associated with fatigue in this cohort.
About 20 years after diagnosis, patients from a cohort with incident IBD were invited to a follow-up visit that included a structured interview, a clinical examination, laboratory tests and the Fatigue Questionnaire (FQ).
|Factors associated with fatigue included self-perceived disease activity|
|Scandanavian Journal of Gastroenterology|
Fatigue scores were obtained, and factors associated with fatigue were assessed via linear and logistic regression analyses.
Of the 599 invited patients, the team found that 74% completed the FQ.
Among those with active disease, the researchers found significantly higher fatigue scores than among those with quiescent disease.
The team noted that fatigue scores of those with quiescent disease were comparable with those of the reference population.
Chronic fatigue was more frequent among IBD patients than in the reference population.
The researchers identified that factors associated with fatigue included self-perceived disease activity, poor sleep quality, anxiety and depression.
Dr Huppertz-Hauss' team concludes, "At 20 years after IBD diagnosis, fatigue scores were higher and chronic fatigue was more frequent among IBD patients with active disease than in the reference population, and among those with quiescent IBD."
"Subjectively perceived disease activity, sleep quality, anxiety and depression were associated with fatigue in IBD patients."