Primary biliary cholangitis is often associated with other autoimmune diseases, but little is known about the influence of thyroid disease on the natural history of primary biliary cholangitis.
Dr Annarosa Floreani and colleagues from Italy analyzed the association between primary biliary cholangitis and thyroid disease, and the latter’s impact on the natural history of primary biliary cholangitis at 2 European centers.
The study involved 921 primary biliary cholangitis patients enrolled between 1975 and 2015 in Padova and Barcelona, with a mean follow-up of 127 months.
Data were recorded on patients’ histological stage at diagnosis, biochemical data, associated extrahepatic autoimmune conditions, and clinical events, including hepatic decompensation.
|A total of 16% had thyroid disease|
|American Journal of Gastroenterology|
The team found that a total of 16% had thyroid disease, including 10% with Hashimoto’s thyroiditis, 2% with Graves’ disease, 2% with multinodular goiter, 1% with thyroid cancer, and 1% with other thyroid conditions.
The researchers found that prevalence of different types of thyroid disease was similar in Padova and Barcelona, except for Graves’ disease and thyroid cancer, which were more frequent in the Padova cohort.
Overall, the team observed no differences between primary biliary cholangitis patients with and without thyroid disease in terms of their histological stage at diagnosis, hepatic decompensation events, occurrence of HCC, or liver transplantation rate.
The presence of associated thyroid disease was not associated with lower survival for primary biliary cholangitis patients in either cohort.
Dr Floreani's team comments, "Thyroid diseases, and autoimmune thyroid disease like Hashimoto’s thyroiditis in particular, are often associated with primary biliary cholangitis, but the presence of thyroid disease does not influence the rate of hepatic complications or the natural history of primary biliary cholangitis."