Fatigue is a frequently reported and predominant symptom experienced by patients with inflammatory bowel disease (IBD) and its impact has been associated with poorer quality of life.
The complex interplay between disease-related variables and potentially modifiable psychosocial factors in IBD-fatigue has yet to be unravelled.
Dr Artom and colleagues from the United Kingdom evaluated the contribution of clinical, sociodemographic and psychosocial factors to the severity and impact of IBD-fatigue and quality of life.
In a cross-sectional study, 182 patients with IBD were recruited from 3 tertiary referral hospitals’ out-patient clinics in London.
|Avoidance behaviors explained an additional 41% of the variance in fatigue impact |
|Alimentary Pharmacology & Therapeutics|
The team assessed fatigue utilizing the Inflammatory Bowel Disease-Fatigue Scale (IBD-F), the Multidimensional Fatigue Inventory (MFI), and quality of life by the Inflammatory Bowel Disease Questionnaire (IBDQ).
Patients completed self-report questionnaires evaluating emotional, cognitive and behavioural factors potentially correlated with fatigue.
The research team collected sociodemographic data.
Disease-related and laboratory data were retrieved from patients’ hospital electronic medical records.
The research team found that disease activity was the only clinical factor consistently associated with severity and impact of fatigue and quality of life.
The team observed that more negative fatigue perceptions were significantly associated with greater IBD-F1 scores.
When controlling for clinical factors, negative perceptions of fatigue, and all-or-nothing and avoidance behaviors explained an additional 41% of the variance in fatigue impact (IBD-F2).
Dr Artom's team concludes, "Apart from disease activity, emotional and behavioural factors and patients’ negative fatigue perceptions may be key factors to be addressed."
"Further exploration of these factors in longitudinal, and intervention studies may help to develop effective models of fatigue management."