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 16 December 2017

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News

Score predicts either activity in adult patients with eosinophilic esophagitis

The Endoscopic Reference Score shows modest accuracy to predict either clinical or histological activity in adult patients with eosinophilic esophagitis, reports the latest Alimentary Pharmacology & Therapeutics.

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Conflicting results have been recently reported for the accuracy of the Endoscopic Reference Score (EREFS), an standardised endoscopic classification, to predict the histological activity of eosinophilic esophagitis.

Dr Rodríguez-Sánchez and colleagues evaluated the accuracy of the EREFS to predict either histological or clinical activity of eosinophilic esophagitis.

The research team conducted a prospective multicenter study in 8 Spanish centers evaluating adult eosinophilic esophagitis patients, either naïve or after treatment. 

Symptoms were evaluated before upper endoscopy through the Dysphagia Symptom Score, whereas researchers scored the EREFS immediately after the endoscopic procedure, unaware of the histological outcome.

The team included 145 eosinophilic esophagitis patients undergoing 240 consecutive endoscopic procedures. 

Edema persisted in 70% of patients despite histological remission
Alimentary Pharmacology & Therapeutics
Exudates, furrows, and a composite score of inflammatory signs accurately predicted histological activity. 

The research team observed that exudates were the only endoscopic sign showing a good correlation with histological outcome after therapy. 

The team noted that furrows and edema persisted in 50% and 70% of patients despite histological remission. 

No endoscopic feature exceeded 70% accuracy to predict histological activity. 

Likewise, no endoscopic finding could adequately predict dysphagia severity. 

Crepe paper mucosa, diffuse exudates and severe rings correlated with higher symptom scores.

Dr Rodríguez-Sánchez's team comments, "Endoscopic findings assessed by the Endoscopic Reference Score did not correlate with histological or clinical disease activity in adult eosinophilic esophagitis patients."

"Only exudates correlated with peak eosinophil count and histological outcome, whereas furrows and edema persisted in over half of patients despite histological remission."

Aliment Pharmacol Ther 2017: 45(2): 300–309
04 January 2017

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