Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia.
Dr Sonnenberg and colleagues from Texas, USA investigated the interaction between ethnicity and Helicobacter pylori infection in the occurrence of Barrett's metaplasia among patients undergoing oesophago-gastro-duodenoscopy.
The Miraca Life Sciences Database is an electronic repository of histopathological patient records.
The team performed a case–control study that evaluated the influence of age, gender, ethnicity and histological diagnosis of Helicobacter pylori on the occurrence of Barrett's metaplasia.
|Male sex exerted the strongest influence on the occurrence of Barrett's metaplasia|
|Alimentary Pharmacology & Therapeutics|
The total study population comprized 596,479 subjects, of whom 76,475 harbored a diagnosis of Barrett's metaplasia.
The team found that male sex, age and Helicobacter pylori infection in declining order exerted the strongest influence on the occurrence of Barrett's metaplasia.
In comparison with the population comprizing Caucasians and African Americans, Barrett's metaplasia was less common among subjects of African, Middle Eastern, East Asian, Indian, Hispanic or Jewish descent, but more common among subjects of Northern European descent.
With the exception of Jews and Northern Europeans, the team noted that all other ethnic subgroups were characterized by a higher prevalence of Helicobacter pylori than the comparison group.
A low prevalence of Helicobacter pylori was significantly associated with a high prevalence of Barrett's metaplasia, as well as dysplasia or esophageal adenocarcinoma.
Dr Sonnenberg's team concludes, "Our analysis reveals an inverse relationship between the prevalence of Barrett's metaplasia and Helicobacter pylori gastritis among different ethnic groups within the United States."