The disease course of acute pancreatitis ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality.
At present, there are no universally accepted and reliable predictors for severity.
Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with acute pancreatitis is not well understood.
Dr Sara Bertilsson and colleagues investigated the value of microproteinuria to predict development of organ failure in acute pancreatitis.
Consecutive acute pancreatitis patients were prospectively enrolled.
The team collected urine samples upon admission, 12–24 hours after admission, and 3 months post-discharge for calculation of urine α1-microglobulin-, albumin-, IgG-, and IgM/creatinine ratios.
Data regarding acute pancreatitis etiology, severity, and development of organ failure were registered.
The researchers evaluated 92 acute pancreatitis patients.
The α1-microglobulin-, albumin-, and IgG/creatinine ratios correlated with high-sensitivity C-reactive protein 48 hours after admission.
The team noted that they were also significantly higher in patients with versus without organ failure.
The research team observed that the α1-microglobulin/creatinine ratio upon admission predicted organ failure with similar accuracy as the more complex APACHE II score.
Dr Bertilsson's team comments, "The α1-microglobulin/creatinine ratio upon presentation with acute pancreatitis is related to inflammation and predicts development of organ failure."
"Further studies are warranted to evaluate its potential usefulness in predicting outcome for acute pancreatitis patients."