The recent increase in our knowledge of human gut microbiota has changed our view on antibiotics.
Antibiotics are, indeed, no longer considered only beneficial, but also potentially harmful drugs, as their abuse appears to play a role in the pathogenesis of several disorders associated with microbiota impairment.
Professor Antonio Gasbarrini and colleagues from Italy reviews the potential of antibiotics in the development of major non-communicable disorders associated with the alteration of gut microbiota.
|Antibiotics are nowadays considered a reliable therapy for some non-communicable disorders|
The team report that both drug-related factors and host-related factors appear to influence the alterations of human gut microbiota produced by antibiotics.
Nevertheless, antibiotics are nowadays considered a reliable therapy for some non-communicable disorders, including IBS or hepatic encephalopathy.
The team observed that some antibiotics can also act positively on gut microbiota, providing a so-called ‘eubiotic’ effect, by increasing abundance of beneficial bacteria.
Therefore, antibiotics appear to change, for better or worse, the nature of several disorders, including IBS, IBD, metabolic disorders or liver disease.
Professor Gasbarrini's team comments, "The team also examined newly discovered therapeutic avenues of antibiotics beyond the cure of infectious diseases."