Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 19 October 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Genome-wide association study of gastric adenocarcinoma

fiogf49gjkf04
Genome-wide association study of gastric adenocarcinoma in Asia reported in the latest issue of Gut compares the associations between cardia and non-cardia tumors.

News image

fiogf49gjkf04

Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism associations for tumor subtypes, particularly when divided by location into the gastric cardia versus the non-cardia.

Dr Christian Abnet and colleagues from Maryland, USA present results for a GWAS using 2350 East Asian gastric cancer cases divided as 1189 gastric cardia and 1027 gastric non-cardia cases and 2708 controls.

The researchers included up to 3042 cardia cases, 4359 non-cardia cases and 7548 controls for replication from 2 Chinese studies and 1 Korean study.

The team confirmed a previously reported association for rs4072037 in MUC1 for total gastric cancer
Gut

From the GWAS, the team selected 12 top single-nucleotide polymorphisms for each gastric cancer subtype, 4 top single-nucleotide polymorphisms for total gastric cancer, and 1 single-nucleotide polymorphism in MUC1 for replication testing.

The research team observed genome-wide significant associations for rs10074991 in PRKAA1 at 5p13.1 for cardia and non-cardia cancers with per allele odds ratio for the combined endpoint of 0.80.

The researchers observed that at 6p21.1, rs2294693 near UNC5CL was significantly associated with gastric non-cardia cancer risk, with odds ratio of 1.18, but there was only a nominal association for cardia cancer.

The team also confirmed a previously reported association for rs4072037 in MUC1 for total gastric cancer and similar estimates for cardia and non-cardia cancers.

The team found that 3 single-nucleotide polymorphisms in PSCA previously reported to be associated with gastric non-cardia cancer showed no apparent association for cardia cancer.

Dr Abnet's team comments, "Our results suggest that associations for single-nucleotide polymorphisms with gastric cancer show some different results by tumor location in the stomach."

Gut 2016;65:1611-1618
10 October 2016

Go to top of page Email this page Email this page to a colleague

 19 October 2017 
Current management of chylous ascites
 19 October 2017 
Fecal immunochemical tests in colorectal cancer screening
 19 October 2017 
Surgical anastomosis at 1-year colorectal cancer surveillance
 18 October 2017 
Hep E seroprevalence and hemodialysis
 18 October 2017 
Prebiotic and changes in the human gut microbiota
 18 October 2017 
Predicting recurrence after curative rectal cancer surgery
 17 October 2017 
Laparoscopic surgery use in Medicare patients with colon cancer
 17 October 2017 
Medication nonadherence and health care costs
 17 October 2017 
Asthma and IBD development
 16 October 2017 
Colorectal cancer screening and postpolypectomy surveillance colonoscopy
 16 October 2017 
Continuity of care after colorectal surgery
 16 October 2017 
Breastfeeding and the risk of IBD
 13 October 2017 
Treating patients with HCV and severe renal impairment
 13 October 2017 
Blood pressure management during abdominal surgery
 13 October 2017 
Food elimination diets for eosinophilic esophagitis
 12 October 2017 
Global recurrence of H. pylori
 12 October 2017 
Colonoscopy in an organized colorectal cancer screening program 
 12 October 2017 
Predicting advanced fibrosis in chronic hepatitis B
 11 October 2017 
Fecal microbiota transplantation for ulcerative colitis
 11 October 2017 
Sexual functioning in Hep C
 11 October 2017 
Ulcerative proctitis in pediatric-onset UC
 10 October 2017 
Quality standards in upper gastrointestinal endoscopy
 10 October 2017 
Eosinophilic esophagitis and swallowed topical corticosteroids
 10 October 2017 
Follow-up of positive results on fecal blood tests
 09 October 2017 
Diverticulitis and emergency department burden
 09 October 2017 
Clostridium difficile infection after ileostomy reversal
 09 October 2017 
Global recurrence rate of H. pylori
 06 October 2017 
Predicting nontreatment for Hep C
 06 October 2017 
Cow's milk–based formula and development of celiac disease
 06 October 2017 
Propofol for outpatient colonoscopy
 05 October 2017 
Pediatric candidates on the transplant wait list
 05 October 2017 
Incidence of sepsis in the USA
 05 October 2017 
Quality of life after chemoradiation in rectal cancer
 04 October 2017 
Peptic ulcer disease diagnosed in acute upper endoscopy
 04 October 2017 
Clinical practice guidelines in colon cancer
 04 October 2017 
Rural residence and risk of IBD
 03 October 2017 
Novel candidate risk genes for IBD
 03 October 2017 
Antibody tests and detecting celiac disease
 03 October 2017 
Environmental factors and IBD
 02 October 2017 
Full publication of Gastroenerology abstracts
 02 October 2017 
Interferon-free therapy in advanced liver disease
 02 October 2017 
Burden of NAFLD with advanced fibrosis in the USA
 29 September 2017 
Inpatient Gastroenterology training experience
 29 September 2017 
Proteomic analysis of IBD
 28 September 2017 
Incidence of biopsy-verified celiac disease
 28 September 2017 
Social networking-based discussion group by ERCP doctors
 27 September 2017 
Function of trypsin-3 in IBS
 27 September 2017 
Predictors of nonadherence in IBD
 27 September 2017 
Hep C treatment in the era of direct-acting anti-viral agents
 26 September 2017 
Chronic pancreatitis and pancreatic cancer risk
 26 September 2017 
Factors associated with the risk of metachronous gastric neoplasm
 26 September 2017 
Treatment of hyperactive delirium in advanced cancer
 25 September 2017 
Lenalidomide for advanced liver cancer
 25 September 2017 
Silibinin nanoparticles inhibit HCV infection
 22 September 2017 
Perforation after colonic endoscopic mucosal resection
 22 September 2017 
Medical management and colectomy rates
 22 September 2017 
MRI for liver metastatic colorectal cancer
 21 September 2017 
Adenomatous colorectal polyps in young cancer survivors
 21 September 2017 
Predicting mucosal healing in treated celiac disease patients
 21 September 2017 
Antireflux surgery and recurrence of GERD

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us