Although the influence of cigarette smoking on the incident risk of liver cancer has been determined, the association between smoking and liver cancer mortality remains uncertain.
Dr Chang Liu and colleagues from China searched Pubmed, EmBase, and Web of Science databases to obtain eligible studies.
Hazard ratio (HR) value and 95% confidential intervals (CI) were pooled by using a random-effects model, and dose–response analyses were conducted to quantify associations between smoking and mortality from liver cancer.
|The risk increased by 7% for each additional 10 cigarettes per day|
|Journal of Gastroenterology & Hepatology|
A total of 27 articles involving 4 million participants from 7 countries by retrieval were finally included.
The research team found that the pooled hazard ratio values for liver cancer mortality was 1.45, 1.22 and 1.16 for current, former, and ever smokers, respectively, when compared with nonsmokers.
The team noted that the risk increased by 7% for per additional 10 cigarettes per day, and by 5% for per additional 10 pack-years.
In 597 patients with liver cancer, smoking status was further identified as a significant determinant factor of tumor size and serum level of gamma-glutamyl transpeptidase, but not a significant prognostic factor.
Dr Liu's team concludes, "Cigarette smoking, especially current smoking, significantly increased mortality risk from liver cancer."