Sleep dysfunction is a highly prevalent condition.
It has long been implicated in accelerating disease states characterized by having an inflammatory component such as systemic lupus erythematosus, HIV, and multiple sclerosis.
Inflammatory bowel disease (IBD) is a chronic, debilitating disease that is characterized by waxing and waning symptoms, which are a direct result of increased circulating inflammatory cytokines.
Dr David Johnson and colleagues from Virginia, USA reviews the association between sleep disorders and inflammatory bowel diseases.
|There is a therapeutic role of sleep cycle in the prevention of IBD flares |
|American Journal of Gastroenterology|
Recent studies have demonstrated sleep dysfunction, and the disruption of the circadian rhythm to result in an upregulation of inflammatory cytokines.
The team report that not only does this pose a potential trigger for disease flares but also an increased risk of malignancy in this subset of patients.
This begs to question whether or not there is a therapeutic role of sleep cycle and circadian rhythm optimization in the prevention of IBD flares.
Dr Johnson's team concludes, "Further research is needed to clarify the role of sleep dysfunction and alterations of the circadian rhythm in modifying disease activity and also in reducing the risk of malignancy in patients suffering from IBD."