Several studies have reported an association between alcoholic liver cirrhosis or other forms of alcoholic liver disease and the genetic variant rs738409 (C>G) in adiponutrin/patatin-like phospholipase domain-containing 3 gene (PNPLA3).
Dr Marcos and colleagues from Spain evaluated the influence of this variant on alcoholic liver cirrhosis and other forms of alcoholic liver disease.
The research team performed a systematic review of previous studies on the relationship between rs738409 of PNPLA3 and alcoholic liver disease and meta-analysis was conducted in a random-effects model.
Calculations of the odds ratios and their confidence intervals, tests for heterogeneity and sensitivity analyses were performed.
|the rs738409 variant of PNPLA3 is clearly associated with alcoholic liver cirrhosis|
|Alimentary Pharmacology & Therapeutics|
The team identified 11 previous studies available for inclusion with a total of 3495 patients with alcoholic liver disease, and 5038 controls.
The researchers found that patients with alcoholic liver cirrhosis compared to controls had a significantly higher prevalence of the G allele when comparing GG vs. CC or GC vs. CC genotypes or under a recessive or dominant model.
The team found similar results when comparing separately patients with alcoholic liver cirrhosis vs. alcoholics without alcoholic liver disease or healthy subjects.
An association of the G allele with alcoholic liver disease emerged when comparing alcoholic liver disease patients vs. alcoholics without alcoholic liver disease and/or healthy subjects although moderate to large heterogeneity was observed.
The team suggested an additive genetic model for this variant in alcoholic liver disease.
Dr Marcos' team concludes, "Our meta-analysis shows that the rs738409 variant of PNPLA3 is clearly associated with alcoholic liver cirrhosis."