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News

Genetic variant associated with alcoholic liver cirrhosis

Tthe I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis, reports this month's issue of the Alimentary Pharmacology & Therapeutics.

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Several studies have reported an association between alcoholic liver cirrhosis or other forms of alcoholic liver disease and the genetic variant rs738409 (C>G) in adiponutrin/patatin-like phospholipase domain-containing 3 gene (PNPLA3).

Dr Marcos and colleagues from Spain evaluated the influence of this variant on alcoholic liver cirrhosis and other forms of alcoholic liver disease.

The research team performed a systematic review of previous studies on the relationship between rs738409 of PNPLA3 and alcoholic liver disease and meta-analysis was conducted in a random-effects model.

Calculations of the odds ratios and their confidence intervals, tests for heterogeneity and sensitivity analyses were performed.

the rs738409 variant of PNPLA3 is clearly associated with alcoholic liver cirrhosis
Alimentary Pharmacology & Therapeutics

The team identified 11 previous studies available for inclusion with a total of 3495 patients with alcoholic liver disease, and 5038 controls.

The researchers found that patients with alcoholic liver cirrhosis compared to controls had a significantly higher prevalence of the G allele when comparing GG vs. CC or GC vs. CC genotypes or under a recessive or dominant model.

The team found similar results when comparing separately patients with alcoholic liver cirrhosis vs. alcoholics without alcoholic liver disease or healthy subjects.

An association of the G allele with alcoholic liver disease emerged when comparing alcoholic liver disease patients vs. alcoholics without alcoholic liver disease and/or healthy subjects although moderate to large heterogeneity was observed.

The team suggested an additive genetic model for this variant in alcoholic liver disease.

Dr Marcos' team concludes, "Our meta-analysis shows that the rs738409 variant of PNPLA3 is clearly associated with alcoholic liver cirrhosis."

Aliment Pharmacol Ther 2014: 40(6): 571–581
01 September 2014

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