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Endoscopic submucosal dissection is safe for superficial squamous esophageal neoplasia

This month's Digestive Diseases & Sciences examines the efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasia.

News image

Although endoscopic submucosal dissection has grown popular in resecting lesions in the stomach, the application of ESD to the esophagus has been limited by greater technical difficulty.

An increasing number of series have recently reported the application of endoscopic submucosal dissection to esophageal lesions.

Dr Joon Sung Kim and colleagues performed a systemic review and meta-analysis to evaluate the efficacy and safety of endoscopic submucosal dissection for esophageal lesions.

Comprehensive literature searches were performed on studies that reported endoscopic submucosal dissection for the removal of esophageal neoplasia.

Primary outcome measures were pooled estimates of complete resection rate and en bloc resection rate.

The pooled estimate of complete resection rate was 89%
Digestive Diseases & Sciences

The team's secondary outcome measures were pooled estimates of complication rates.

The research team identified a total of 15 studies that provided data on 776 endoscopic submucosal dissection-treated lesions.

The pooled estimate of complete resection rate was 89%.

The researchers found that the pooled estimate of en bloc resection was 95%.

The team noted that pooled estimates of complications of endoscopic submucosal dissection such as bleeding, perforation, and stenosis were 2, 5, and 12%, respectively.

Dr Kim's team commented, "Endoscopic submucosal dissection appeared to be an extremely effective technique to achieve complete resection of esophageal neoplasia."

"The very low rate of complications also shows the potential safety of this approach."

Dig Dis Sci 2014: 59(8): 1862-1869
22 August 2014

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