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Is a stricter colonoscopy screening protocol necessary in liver transplant recipients?

August's Diseases of the Colon & Rectum evaluated the prevalence of colorectal neoplasm in liver transplantation recipients, and compared it with that in the average-risk population.

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The epidemiology of colorectal neoplasm in liver transplantation recipients has not been fully determined.

Dr Ho-Su Lee and colleagues evaluated the prevalence of colorectal neoplasm in liver transplantation recipients, and compared it with that in the average-risk population.

The research team team performed a retrospective and observational study conducted at a tertiary care center.

From 2000 to 2011, 257 liver transplantation recipients who had undergone posttransplant colonoscopy were enrolled.

A total of 1028 control subjects matched for age, sex, and calendar year of the index colonoscopy were recruited from those who had undergone screening colonoscopy at the researchers' institution.

The team compared colonoscopy findings between the 2 groups.

The prevalence of overall colorectal neoplasm was 35% in liver transplantation recipients
Diseases of the Colon & Rectum

The prevalence of overall and advanced colorectal neoplasms and their risk factors were investigated.

The team reported that the median age was 54 years, and each group consisted of approximately 76% men.

The researchers found that the prevalence of overall and advanced colorectal neoplasm was 35% and 6% in liver transplantation recipients, and 42% and 4% in controls.

The prevalence of invasive colorectal cancer was higher in liver transplantation recipients than in controls.

The team observed that the prevalence of overall and advanced colorectal neoplasms in liver transplantation recipients younger than 40 years was higher than age-matched controls.

Dr Lee's team comments, "The prevalence of colorectal neoplasms may not increase in liver transplantation recipients compared with the general population."

"However, the prevalence of invasive colorectal cancer may be higher in liver transplantation recipients."

"A prospective study is warranted to determine an appropriate colorectal cancer screening strategy for liver transplantation recipients."

Dis Colon Rectum 2014: 57(8): 976982
04 August 2014

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