Studies on the relation between alcohol consumption and risk of colorectal adenoma (CRA), a precursor of colorectal cancer, have been inconsistent.
Professor Li and colleagues from China conducted a systematic review with meta-analysis to investigate the association and the dose–response of alcohol with colorectal adenoma.
A literature search was performed on PubMed to identify relevant studies published up to 2014.
The team included 23 case–control studies and 2 cohort studies in the meta-analysis.
|For drinkers of 50 g/day alcohol consumption, the estimated relative risk was 1.16|
|Alimentary Pharmacology & Therapeutics|
The team observed that all drinkers were associated with 17% increased risk for colorectal adenoma, compared with nondrinkers or occasional alcohol drinkers.
The dose–response analysis demonstrated that for drinkers of 10, 25, 50 and 100 g/day alcohol consumption, the estimated relative risks of colorectal adenoma were 1.02, 1.06, 1.16, and 1.61, respectively, in comparison with non-/occasional drinkers.
The research team found that risks were consistent in the subgroup analyses of gender and site of adenoma, while it was stronger in European studies than the studies in the US and Asia.
Professor Li and team comment, "This study suggests that alcohol intake is related to a significant increase of risk for colrectal adenoma."