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 14 February 2016

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News

Mortality after total colectomy in IBD

August's issue of the Alimentary Pharmacology & Therapeutics investigates the 40-day mortality following colectomy in patients with IBD.

News image

A high post-operative mortality has been reported following colectomy in patients with inflammatory bowel disease (IBD), especially in some patient groups.

Dr Nordenvall and colleagues from Sweden investigated the 40-day mortality following colectomy in patients with IBD.

The team's secondary aim was to assess whether colectomised IBD patients have an increased mortality compared to the general population.

This is a population-based register study of all patients with IBD in Sweden who underwent total colectomy in 2000–2010.

The cohort was identified using international classification codes for ulcerative colitis (UC) and Crohn's disease (CD).

Patients registered with both UC and CD before colectomy (UCCD) were analyzed separately.

The team followed each patient up to the date of death, migration or 31st of December 2010, whichever came first.

Kaplan–Meier survival curves, Cox proportional hazards models and relative mortality rates were used to describe mortality.

In the cohort of 3084 patients, 2424 were diagnosed with UC, 326 with CD and 334 with UCCD.

The research team found that the 40-day, 1-year and 3-year mortality was 1%, 3% and 6%, respectively.

The team observed that the highest 40-day mortality was seen in patients ≥59 years of age.

The researchers found that colectomy at the primary hospitalization for IBD did not significantly increase the risk of post-operative mortality, nor did hospital volume.

The relative survival after 3 years was 0.99, 0.98, 0.97 and 0.90 in those <30, 30–43, 44–58 and ≥59 years old, respectively.

Dr Nordenvall's team concludes, "The 40-day mortality following total colectomy in IBD patients in Sweden is low, except in patients ≥59 years old."

Aliment Pharmacol Ther 2014: 40(3): 280–287
16 July 2014

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